WE ARE RARE
Fulcrum is a great place to have a career. Why? Because we have the FULcrew! Our people make us great. At Fulcrum, you can count on finding coworkers who are passionate about their work. Our patient-centered, inclusive, and connected culture enables us to actively listen to the needs of the rare disease community as we lead our science. This makes us and our work rare!
Make your career a career with impact.
See our available roles below or connect with us at careers@fulcrumtx.com
Voices of Fulcrum
Meet the FULcrew and hear our stories.
Are you looking for consistency, commitment, and passion in your career? Join us.
There is always hope for change when people are committed to moving forward together every day, without exception. We call this steadfast commitment our "20 Mile March," inspired by Jim Collins' book Good to Great. At Fulcrum, we pledge to show up passionately every day, dedicated to our work and each other, no matter the challenges we face.
Explore our job openings:
Director, Patient Advocacy
Company Overview
Fulcrum Therapeutics, Inc. (“Fulcrum”) [NASDAQ: FULC] is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s lead program in clinical development is pociredir, a small molecule designed to increase the expression of fetal hemoglobin for the treatment of sickle cell disease (SCD).
Description
Reporting to Head of Patient Advocacy, the Director of Patient Advocacy will oversee both the strategic and operational aspects of Fulcrum’s efforts to integrate the patient experience from discovery to commercialization. This position will vertically and horizontally integrate the patient experience into Fulcrum’s operating model to ensure the patient experience we deliver is best-in class. A focus on authenticity at every phase of the patient journey at Fulcrum will ensure all patients feel they are part of the Fulcrew while engaging with Fulcrum.
Responsibilities
Working cross-functionally with internal stakeholder including Government Affairs, Program Management, Program Leadership, Medical Affairs, and Clinical Operations
- In partnership with the Head of Patient Advocacy, build strategic roadmap of patient experience from discovery to commercialization that reflects insights and strategies that help elevate Fulcrum with the communities that it serves.
- Identify opportunities to generate insights and analytics related to patient and caregiver needs across the patient journey and spearheads the execution of these projects in conjunction with the patient services execution team.
- Supports both federal and state policy strategic planning activities to ensure that Fulcrum is positioned well to capital.
- Develop and maintain comprehensive, innovative, value-creating patient experience strategies, ensuring they maintain strategic prominence with key stakeholders!
- Identify industry best practices as well as innovative access services approaches that can improve the ability of Fulcrum to support patients.
- Monitor policy developments to ensure that Fulcrum is well informed and appropriately prepared for the evolving government oversight, regulatory environment, legal, and reputational landscape surrounding manufacturer-sponsored Access Services programs.
- Serve as a strategic planning resource to our internal teams in developing patient services resources across Fulcrum.
Qualifications
- Bachelor’s degree (Advanced degree preferred)
- Have worked in a pre-commercial or commercial rare disease company (preferred)
- 5+ years of a demonstrated track record of developing and implementing patient services programs and patient focused access solutions
- Recognized profile in the industry as a thought leader in patient support and documented ability to engage Senior Leadership on patient-focused support solutions
- Strong, demonstrated track record of connecting and combining ideas, designing pilots and metrics, and driving novel ideas to practical solutions across patient support teams
- Deep understanding of how to identify and address the emotional, physical, and financial barriers patients experience regarding obtaining their prescribed medications
- Understanding of the complex legal, regulatory, and compliance regulations and guidelines around access support program development and execution
Director/Sr. Director, Head of Preclinical Benign Hematology
Company Overview
Fulcrum Therapeutics, Inc. (“Fulcrum”) [NASDAQ: FULC] is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s lead program in clinical development is pociredir, a small molecule designed to increase the expression of fetal hemoglobin for the treatment of sickle cell disease (SCD).
Description
Reporting to our Chief Scientific Officer, the Head of PreClinical Hematology will be a highly driven scientific leader who is dedicated to performing great science that transforms patients’ lives. They are drug hunters and will lead our Benign Hematology team, playing a pivotal role in discovery strategy and in building the portfolio. The successful candidate will partner with colleagues in medicinal chemistry, DMPK and in vivo pharmacology to translate scientific discoveries into new medicines. This is a forward-facing leadership role, requiring cross-functional collaboration, establishing liaisons with KOLs, and routine interface with members of our Clinical Team, Executive Team and Board of Directors. As a highly experienced scientist, the Head of PreClinical Hematology is expected to play a large role in the mentorship and development of their team, fostering a growth-from-within mindset in the art of drug discovery.
Responsibilities
- Guide scientific research with the goal of discovering transformative first-in-class medicines
- Supervise Project Team Leaders who are driving cross-functional discovery programs
- Lead, mentor, and coach your team of direct reports in the art and science of drug discovery
- Work cross-functionally with team and colleagues to design work streams focused on elucidating new target biology for various rare Benign Hematology indications
- Leverage disease biology and drug discovery expertise to validate targets and build pharmacological relationships across a diversity of fit-for-purpose pre-clinical models, building robust in vitro and in vivo pharmacology data packages
- Implement a translational biology strategy for later-stage discovery programs, identifying candidate target-engagement and therapeutic biomarkers for clinical exploration
- In-source capability and out-source capacity by establishing strategic and highly productive partnerships with leading CROs; teach your team how to lead in the absence of a line reporting relationship through your effective management of these relationships
- Collaborate with stakeholders in clinical development, business development, and commercial to set long-term strategy and establish new opportunities for the Benign Hematology franchise
- Work with Business Development team to generate content for partnership discussions and perform due diligence for on-strategy in-licensing opportunities
- Interface with internal and external KOL networks for input on target hypotheses, models, and technologies
- Participate as an active thought partner in the overall company strategy; periodically present to the Executive Team and the Board of Directors
Qualifications
- Ph.D. in biology, physiology, molecular and/or cellular biology with 10+ years of industry experience in the hematology arena
- Proven track record of performing research with the goal of discovering new medicines; has served as a project team leader or co-leader for a drug discovery program that successfully identified a development candidate
- Experienced team leader who effectively manages external collaborations and service providers with the ability to bring a pragmatic business-minded approach to balancing internal and external capabilities
- Experience managing PhD-level reports
- Desire to learn and tackle new challenges and initiatives; responds to stress with humor and professionalism
- Possesses a high degree of scientific discretion, intuition and integrity
- Strong written and verbal communication skills; able to communicate effectively to non-technical audiences
- Fosters a collaborative and inclusive environment
