WE ARE RARE
Fulcrum is a great place to have a career. Why? Because we have the FULcrew! Our people make us great. At Fulcrum, you can count on finding coworkers who are passionate about their work. Our patient-centered, inclusive, and connected culture enables us to actively listen to the needs of the rare disease community as we lead our science. This makes us and our work rare!
Make your career a career with impact.
See our available roles below or connect with us at careers@fulcrumtx.com
Voices of Fulcrum
Meet the FULcrew and hear our stories.
Are you looking for consistency, commitment, and passion in your career? Join us.
There is always hope for change when people are committed to moving forward together every day, without exception. We call this steadfast commitment our "20 Mile March," inspired by Jim Collins' book Good to Great. At Fulcrum, we pledge to show up passionately every day, dedicated to our work and each other, no matter the challenges we face.
Explore our job openings:
Director/Senior Director, Head of Publications
About Fulcrum Therapeutics
Fulcrum Therapeutics, Inc. (“Fulcrum”) [NASDAQ: FULC] is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s lead program in clinical development is pociredir, a small molecule designed to increase the expression of fetal hemoglobin for the treatment of sickle cell disease (SCD).
Position Summary
The Head of Publications will be responsible for leading the development and implementation of Fulcrum’s global publication strategy —including original scientific manuscripts, abstracts, and materials for scientific and patient advocacy audiences. This role will also oversee the timely and high-quality dissemination of clinical and health economics and outcomes research (HEOR) data, as well as the company’s representation across social media platforms.. Reporting to the Vice President, Clinical Development, this role will work cross-functionally with Clinical Development, Medical Affairs, and Regulatory teams to align publication activities with corporate and scientific communication objectives.
This is a hybrid role based in Cambridge, MA, requiring a minimum of 3 days on-site per week.
Key Responsibilities
- Develop and execute a comprehensive global publication strategy, ensuring alignment with Fulcrum’s scientific and medical objectives.
- Lead the planning, development, and dissemination of high-quality scientific publications, including manuscripts, abstracts, posters, and congress presentations.
- Collaborate cross-functionally with Clinical Development, Medical Affairs, and other key stakeholders to ensure a cohesive and strategic approach to data communication.
- Manage external agencies, writers, and vendors, ensuring publications adhere to timelines, budgets, and industry standards (ICMJE, GPP, etc.).
- Drive innovative approaches to scientific publications, including digital platforms and emerging communication channels.
- Ensure compliance with ethical, legal, and regulatory guidelines, including transparency and data-sharing requirements.
- Establish and oversee an efficient publication review process, maintaining scientific integrity, accuracy, and alignment with corporate messaging.
- Track and report key publication metrics to assess impact, optimize strategy, and drive continuous improvement.
- Provide leadership and mentorship to internal team members, fostering professional development and scientific excellence.
Qualifications
- Advanced degree (PhD, PharmD, MD, or equivalent) in a relevant scientific discipline.
- Minimum of 10 years of experience in medical publications within the biotech or pharmaceutical industry, ideally in rare diseases with focus on basic, translational and clinical research in benign and malignant hematology.
- Strong understanding of the publication process, industry guidelines, regulatory, scientific and GCP requirements.
- Track record of publications ideally related to basic, translational, and clinical research in benign and malignant hematology or rare genetically defined disease, featured in high-impact journals and presented at leading scientific meetings.Established network with leading KOLs and other key stakeholders relevant to the successful execution of a publication strategy.
- Experience and ability to plan and translate scientific literature into documents appropriate for non-scientific audiences, including patient advocacy groups, government affairs, and investors.
- Proven track record of developing and executing successful publication plans across multiple therapeutic areas.
- Experience working in a matrixed environment and leading cross-functional teams.
- Excellent communication and project management skills, with the ability to manage multiple priorities effectively.
- Experience with digital publication platforms and innovative publication strategies is a plus.
- Demonstrated ability to manage external vendors and publication budgets effectively.
Principal Scientist and Head of Molecular Pharmacology
Company Overview
Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum is deeply committed to bringing hope and new options to patients suffering from rare hematologic diseases, and is developing a pipeline of clinical and preclinical assets. Fulcrum’s lead clinical asset is Pociredir, a first-in-class small molecule designed to increase the expression of fetal hemoglobin for the treatment of sickle cell disease and other hemoglobinopathies, including beta-thalassemia. Fulcrum’s preclinical pipeline includes novel treatments for Inherited Bone Marrow Disorders, with an emphasis on the discovery and development of novel therapeutic agents for the potential treatment of Diamond-Blackfan Anemia (DBA). We are actively expanding our preclinical benign hematology pipeline and seek an enthusiastic and experienced leader to head our assay development efforts.
Description
The Head of Molecular Pharmacology will be a highly driven scientific leader who is dedicated to performing great science that transforms patients’ lives. They are drug hunters and will lead our Molecular Pharmacology function, playing a pivotal role in discovery strategy and in building the early-stage portfolio. The successful candidate will partner with colleagues in biology and medicinal chemistry to develop and implement innovative assay strategies for new projects. As a highly experienced and technically proficient scientist, the Head of Molecular Pharmacology is expected to play a large role in the mentorship and development of their team, exemplifying a “lead-from-the-bench” approach to achieving results in a fast-paced work environment.
Responsibilities
- Guide scientific research with the goal of enabling the discovery of first-in-class treatments for various benign hematology indications
- Supervision of a team of internal and external cell biologists and enzymologists toward enabling both cell-based and biochemical assays for discovery of novel hits and prosecution of active drug discovery efforts
- Hands-on contribution to assay development and troubleshooting
- Work cross-functionally with team and colleagues to design and implement strategies to confirm and elucidate new target biology
- Provide expertise to phenotypic assay deconvolution efforts
- Protein construct design for crystallography and potency/biophysical assays
- Support of biomarker discovery efforts to enable future clinical programs
- In-source capability and out-source capacity by establishing strategic and highly productive partnerships with leading CROs; teach your team how to lead in the absence of a line reporting relationship through your effective management of these relationships
- Interface with internal and external KOL networks for input on target hypotheses, models, and technologies
Qualifications
- PhD in Biochemistry, Chemistry, or a similar discipline
- 8+ years of professional assay development experience for small molecule therapeutics, with expertise in both biochemical and cell-based formats
- Deep understanding of enzymology and drug-target kinetics
- Experience optimizing assays for high-throughput screening, designing and managing screening campaigns
- Familiarity with ELISA, MS, HPLC, SPR, RT-qPCR, TR-FRET, and high content imaging techniques
- Multiomics target ID and phenotypic screening deconvolution a plus
- Experience in the benign hematology space and working with hematopoietic lineage cells is desirable
- Proven track record of performing research with the goal of discovering new medicines; has served as a project team leader or co-leader for a drug discovery program that successfully identified a development candidate
- Experience managing PhD-level reports and the ability to successfully manage both cell biology and enzymology specialists
- Desire to learn and tackle new challenges and initiatives; responds to stress with humor and professionalism
- Possesses a high degree of scientific discretion, intuition and integrity
- Strong written and verbal communication skills; able to communicate effectively to non-technical audiences
- Fosters a collaborative and inclusive environment
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